E-MTAB-4231 - Transcriptomic study of human liver biopsies in obese patients with low and high liver fat
Submitted on 3 December 2007, last updated on 2 February 2016, released on 3 February 2016
Non-alcoholic fatty liver disease (NAFLD) is a major risk factor leading to chronic liver disease and type 2 diabetes. In this study liver metabolic activity and functionality in NAFLD was charted by integrating global transcriptomic data within a genome-scale model of human metabolism. Gene expression was measured in the human liver of eight subjects with extreme steatosis diagnosed with NAFLD (liver fat % range 20-80%), and eight healthy, but obese subjects with low liver fat content (liver fat % range 0-10%).
transcription profiling by array, disease state design
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, E. Ruppin, Matej Oresic. Nature Communications 7:8994 (2016)
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Hyötyläinen T, Jerby L, Petäjä EM, Mattila I, Jäntti S, Auvinen P, Gastaldelli A, Yki-Järvinen H, Ruppin E, Orešič M. :8994 (2016), PMID:26839171