E-MTAB-4085 - RNA-Sequencing of wild type and UCP1-null beige adipose tissue
Last updated on 27 October 2017, released on 28 October 2017
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the roles of classical brown and beige adipocytes, increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to analyze transcriptome of wild type and UCP1-null beige adipocyte to identify the UCP1-independent function.
RNA-seq of coding RNA, genetic modification design, genotype design