E-MTAB-4085 - RNA-Sequencing of wild type and UCP1-null beige adipose tissue
Submitted on 24 November 2015, last updated on 27 October 2017, released on 28 October 2017
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type 2 diabetes. As we better understand the roles of classical brown and beige adipocytes, increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to analyze transcriptome of wild type and UCP1-null beige adipocyte to identify the UCP1-independent function.
RNA-seq of coding RNA, genetic modification design, genotype design