E-MTAB-4065 - Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching

Status
Submitted on 21 September 2015, last updated on 3 February 2017, released on 4 February 2017
Organism
Homo sapiens
Samples (16)
Protocols (3)
Description
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling. In addition, FOXA2 and RUNX2 well known transcription factors in other cancer types were also differentially expressed in the buds compared to the main tumour mass, hinting at the potential role in tumour budding and initiation of metastasis in colorectal cancer.
Experiment types
RNA-seq of coding RNA, development or differentiation design
Contact
Citation
Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching. Linde De Smedt, Sofie Palmans, Matthieu Moisse, Bram Boeckx, Dominiek Smeets, Olivier Govaere, Jasper Wouters, Jeroen Dekervel, Daan Andel, Thomas Tousseyn, Gert De Hertogh, Sabine Tejpar, Diether Lambrechts, Xavier Sagaert.
MINSEQE
Exp. designProtocolsVariablesProcessedSeq. reads
Files
Investigation descriptionE-MTAB-4065.idf.txt
Sample and data relationshipE-MTAB-4065.sdrf.txt
Links