E-MTAB-4065 - Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching
Submitted on 21 September 2015, last updated on 3 February 2017, released on 4 February 2017
Tumour buds undergo phenotype switching while detaching from the main tumour, as they acquire more migratory characteristics and tend to stop proliferating. Simultaneously, an EMT-like signature is observed in the tumour buds under the form of active WNT, TGF and receptor tyrosine kinase signalling. In addition, FOXA2 and RUNX2 well known transcription factors in other cancer types were also differentially expressed in the buds compared to the main tumour mass, hinting at the potential role in tumour budding and initiation of metastasis in colorectal cancer.
RNA-seq of coding RNA, development or differentiation design
Expression profiling of budding cells in colorectal cancer suggests an EMT-like phenotype and molecular subtype switching. Linde De Smedt, Sofie Palmans, Matthieu Moisse, Bram Boeckx, Dominiek Smeets, Olivier Govaere, Jasper Wouters, Jeroen Dekervel, Daan Andel, Thomas Tousseyn, Gert De Hertogh, Sabine Tejpar, Diether Lambrechts, Xavier Sagaert.