E-MTAB-3501 - Gene expression profiles of Rif1 conditional knock-out large T immortalized mouse embryonic fibroblast
Submitted on 7 April 2015, last updated on 15 December 2015, released on 24 December 2015
Mammalian Rif1 defines the architecture of replication-timing domains interactions through the three-dimensional organization of the nuclear volume. Deletion of RIf1 in mammalian cells causes an initial alteration of three-dimensional chromatin organization which impacts first on replication timing and genome stability, but has long-term indirect repercussions also on gene expression.
transcription profiling by array, genetic modification design