E-MTAB-34 - Strain abundance assay of barcoded heterozygous and homozygous yeast single gene deletion strains exposed to 87 psychoactive drugs
Released on 7 July 2008, last updated on 3 June 2014
To profile off-target effects of psychoactive drugs, 87 genome-wide drug fitness assays (of which 5 were performed in duplicate) and 18 genome-wide control experiments were performed in Saccharomyces cerevisiae. Heterozygous and homozygous yeast single gene deletion strains from the BY collection of the Saccharomyces cerevisiae genome deletion consortium were used.
RNAi profiling by array, compound treatment, growth condition, in vivo, strain abundance
Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast. Ericson E, Gebbia M, Heisler LE, Wildenhain J, Tyers M, Giaever G, Nislow C. :e1000151 (2008), Europe PMC 18688276
Off-Target Effects of Psychoactive Drugs Revealed by Genome-wide Assays in Yeast. Elke Ericson, Marinella Gebbia, Lawrence E. Heisler, Jan Wildenhain, Myke Tyers, Guri Giaever, Corey Nislow.