E-MTAB-3313 - All trans-retinoic acid (ATRA) effect on triple negative (TNBC) and luminal (LumA/LumB) primary breast tumors

Status
Submitted on 31 December 2014, last updated on 11 February 2015, released on 31 March 2015
Organism
Homo sapiens
Samples (32)
Array (1)
Protocols (4)
Description
We performed whole genome gene expression microarrays on short-term cultures of mammary tumors deriving from diagnostic Tru-cut procedures of 16 patients in order to evaluate transcriptional response to the retinoid. Tissue slices were challenged with vehicle (DMSO) or ATRA 0.1åµm for 48 hours. The panel consisted of 11 luminal (7xLumA / 4xLumB) and 5 triple negative (TN) primary tumors. All the LumA and LumB tumors were characterized by >70% ER+ cells.
Experiment types
transcription profiling by array, compound treatment design
Contact
Citations
Retinoids and breast cancer: from basic studies to the clinic and back again. Garattini E, Bolis M, Garattini SK, Fratelli M, Centritto F, Paroni G, Gianni' M, Zanetti A, Pagani A, Fisher JN, Zambelli A, Terao M. , PMID:24480385
A novel microRNA fingerprint inversely associated with breast cancer progression. James Fisher , Mineko Terao , Maddalena Fratelli , Mami Kurosaki , Gabriela Paroni , Adriana Zanetti , Maurizio Gianni' , Marco Bolis , Monica Lupi , Anna Tsykin , Gregory Goodall, Enrico Garattini.
Structure and evolution of vertebrate aldehyde oxidases: from gene duplication to gene suppression. Kurosaki M, Bolis M, Fratelli M, Barzago MM, Pattini L, Perretta G, Terao M, Garattini E. , PMID:23263164
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-3313.idf.txt
Sample and data relationshipE-MTAB-3313.sdrf.txt
Raw data (3)E-MTAB-3313.raw.1.zip, E-MTAB-3313.raw.2.zip, E-MTAB-3313.raw.3.zip
Array designA-MEXP-2320.adf.txt