E-MTAB-3243 - Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx
Released on 24 December 2014, last updated on 21 January 2015
Methylated DNA Immunoprecipitation (meDIP) was used to pull down regions of methylated genomic DNA from beta and alpha cell lines (MIN6 and alpha-TC1, respectively). Agilent promoter tiling array was used to look for regions of differential methylation around key endocrine cell fate determination genes.
methylation profiling by array, cell type comparison design
Pancreatic beta cell identity is maintained by DNA methylation-mediated repression of Arx. Dhawan S, Georgia S, Tschen SI, Fan G, Bhushan A.