E-MTAB-3153 - Microarray analysis of DNA methylation in metastatic versus non metastatic breast cancers

Status
Submitted on 29 July 2010, released on 20 March 2015, last updated on 8 July 2016
Organism
Homo sapiens
Samples (38)
Array (1)
Protocols (7)
Description
19 non-metastatic breast cancers (controls) and 19 breast cancers showing metastases or metastatic relapse within 5 years (cases) were extracted from a multi-institutional case series of 123 breast cancer patients . Cases and controls were analyzed for DNA methylation over 56 genes by the MethDet assay [1]using a dedicated microarray (MethDet56). 1. Levenson VV, Melnikov AA: The MethDet: a technology for biomarker development. Expert Rev Mol Diagn 2011, 11:807-812.
Experiment types
methylation profiling by array, case control design
Contact
Citations
A seven-gene CpG-island methylation panel predicts breast cancer progression. Yan Li, Anatoliy A. Melnikov, Victor Levenson, Emanuela Guerra, Pasquale Simeone, Saverio Alberti and Youping Deng. BMC Cancer 15:417 (2015), PMID:25986046
A seven-gene CpG-island methylation panel predicts breast cancer progression. Li Y, Melnikov AA, Levenson V, Guerra E, Simeone P, Alberti S, Deng Y. :417 (2015), PMID:25986046
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-3153.idf.txt
Sample and data relationshipE-MTAB-3153.sdrf.txt
Raw data (1)E-MTAB-3153.raw.1.zip
Array designA-MTAB-539.adf.txt