E-MTAB-280 - mRNA profile of 5-aza-CR and 5-aza-CdR treated celllines
Last updated on 9 June 2014, released on 13 June 2014
5-azacytidine and 5-aza-2'-deoxycytidine are both demethylating agents but they have shown different clinical efficiency. Since 5-azacytidine is incorporated into RNA it might have a different impact on the expression profile than 5-aza-2'-deoxycytidine. This study is designed to investigate the immediate action of the DNMTi on day 2 and the late heritable effects on day 8 after start of treatment.
transcription profiling by array, compound treatment design, time series design
Equitoxic doses of 5-azacytidine and 5-aza-2'deoxycytidine induce diverse immediate and overlapping heritable changes in the transcriptome. Qiu X, Hother C, Ralfkiær UM, Sogaard A, Lu Q, Workman CT, Liang G, Jones PA, Gronbæk K.