E-MTAB-2741 - Transcription profiling by array of mammary epithelium to identify genes which may be important for regulation of mammary stem cell function
Released on 1 November 2014, last updated on 30 June 2015
The aim of the experiment was to produce a mammary stem cell gene signature based on very high purity isolation of mouse mammary stem cells. Gene expression in the stem cells would be compared to gene expression in other cell types from the mammary epithelium to identify genes which may be important for regulation of mammary stem cell function.
transcription profiling by array, cell type comparison design, co-expression, in vivo
Mouse mammary stem cells express prognostic markers for triple-negative breast cancer. Soady KJ, Kendrick H, Gao Q, Tutt A, Zvelebil M, Ordonez LD, Quist J, Tan DW, Isacke CM, Grigoriadis A, Smalley MJ. :31 (2015), PMID:25849541