E-MTAB-2738 - Expression profiling of ncRNAs with custom microarray in 3, 10 and 20 month old wild type and 3xTG AD mice
Submitted on 30 September 2013, last updated on 28 October 2014, released on 31 October 2014
In this study, we particularly focused on short ncRNA expression profiling of three, ten and twenty month old triple transgenic mouse model for Alzheimers disease (Oddo et al.; 2003;Neuron). These mice harbor presenilin PS1(M146V), APP(Swedish) and tau(P301L) mutations and develop beta-amyloid plaques and at later stages also a tau pathology. Controls are age matched B6129SF2/J mice.
transcription profiling by array, dye swap design
Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases. Ronald Gstir, Simon Schafferer, Marcel Scheideler, Matthias Misslinger, Matthias Griehl, Nina Daschil, Christian Humpel, Gerald J. Obermair, Claudia Schmuckermair, Joerg Striessnigm Bernhard E. Flucher and Alexander Hüttenhofer. RNA 20(12):1-15 (2014), PMID:25344396
Generation of a neuro-specific microarray reveals novel differentially expressed noncoding RNAs in mouse models for neurodegenerative diseases. Gstir R, Schafferer S, Scheideler M, Misslinger M, Griehl M, Daschil N, Humpel C, Obermair GJ, Schmuckermair C, Striessnig J, Flucher BE, Hüttenhofer A. :1929-1943 (2014), PMID:25344396