E-MTAB-2675 - CIT-CHEF

Status
Released on 15 June 2015, last updated on 27 September 2018
Organism
Homo sapiens
Samples (51)
Array (1)
Protocols (5)
Description
Fibrolamellar hepatocellular carcinoma (FLC) is a rare type of primary liver cancer that often arises in children, adolescents and young adults. At the pathological level, FLC display pure morphology or can present with mixed morphology involving a conventional HCC component. Owing to the rarity of the disease, its genetic landscape is fully unknown. Pure FLC showed less chromosomic aberrations than mixed FLC and hepatocellular carcinoma arising in non-cirrhotic liverᄉ. Nevertheless; they displayed more gains in 16q23 and more LOH in 21q22. We also analyzed the mutational landscape of 8 FLC by whole-exome sequencing and showed mutations in the coagulation pathway.
Experiment types
genotyping by array, genotyping, innate behavior design, normalization testing design
Contact
Citation
Genomic Landscape of Fibrolamellar Hepatocellular Carcinoma. S. Job,G. Malouf,E. Raymond.
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-2675.idf.txt
Sample and data relationshipE-MTAB-2675.sdrf.txt
Raw data (3)E-MTAB-2675.raw.1.zip, E-MTAB-2675.raw.2.zip, E-MTAB-2675.raw.3.zip
Array designA-GEOD-6986.adf.txt