E-MTAB-2544 - RNA-seq of coding RNA from whole brain hemispheres of the 75 most tame and 75 most aggressive rats of an F2 intercross of rat lines selected for tame and aggressive behavior towards humans
Released on 27 August 2014, last updated on 2 September 2014
mRNA Sequencing was done in whole brain hemispheres of the 75 most tame and 75 most aggressive rats of an F2 intercross of rat lines selected for tame and aggressive behavior towards humans. The brain gene expression levels are associated with 1728 genetic markers across the genome to identify expression QTL (eQTL). Genes whose expression is influenced by the same genetic loci that also influence tameness are candidate genes for tame and aggressive behavior. The list of genetic markers can be found in the supplementary materials of the paper for this study. A series of genotype data spreadsheets and associated data processing protocol are available from http://www.ebi.ac.uk/arrayexpress/files/E-MTAB-2544/E-MTAB-2544.additional.1.zip.
RNA-seq of coding RNA, co-expression, ex vivo, innate behavior design
Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and Aggression. Henrike O. Heyne, Susann Lautenschlaeger, Ronald Nelson, Francois Besnier, Maxime Rotival, Alexander Cagan, Rimma Kozhemyakina, Irina Z. Plyusnina, Lyudmila Trut, Oerjan Carlborg, Enrico Petretto, Leonid Kruglyak, Svante Paabo, Torsten Schoeneberg, Frank W. Albert.