E-MTAB-2520 - Laf4/Aff3 is required for normal neuronal migration

Status
Last updated on 23 April 2014, released on 1 July 2014
Organism
Mus musculus
Samples (8)
Array (1)
Protocols (6)
Description
The aim of this study was to investigate the function of Laf4 in the brain by focusing on its role in the developing cortex. By manipulating expression levels in organotypic slices, we demonstrate that Laf4 is required for normal cellular migration in the cortex and have subsequently identified Mdga2, an important structural protein in neurodevelopment, as a direct target of Laf4 transcriptional activity.
Experiment types
transcription profiling by array, co-expression, development or differentiation design, ex vivo
Contact
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-2520.idf.txt
Sample and data relationshipE-MTAB-2520.sdrf.txt
Raw data (1)E-MTAB-2520.raw.1.zip
Array designA-AFFY-130.adf.txt
Links