E-MTAB-2520 - Laf4/Aff3 is required for normal neuronal migration
Last updated on 23 April 2014, released on 1 July 2014
The aim of this study was to investigate the function of Laf4 in the brain by focusing on its role in the developing cortex. By manipulating expression levels in organotypic slices, we demonstrate that Laf4 is required for normal cellular migration in the cortex and have subsequently identified Mdga2, an important structural protein in neurodevelopment, as a direct target of Laf4 transcriptional activity.
transcription profiling by array, co-expression, development or differentiation design, ex vivo