E-MTAB-2369 - Differential gene expression in CNS after scrapie infection
Released on 1 June 2014, last updated on 3 June 2014
Sheep scrapie is a transmissible spongiform encephalopathy (TSE), which are invariably fatal neurodegenerative diseases of the central nervous system (CNS). Accumulation of the misfolded prion protein, PrPSc in the CNS results in progressive neurodegenerative disease. Susceptible VRQ homozygous New Zealand Cheviot sheep were infected with standard scrapie sheep prion (SSBP/1) scrapie by inoculation in the drainage area of the prescapular lymph nodes. PrPSc was consistently detected by immunohistology in the CNS at XX days post infection (dpi). This study compares the genes and physiological pathways that are affected by the progression of TSE disease in the CNS, focusing on time points immediately before (XX dpi) and after (XX dpi) the detection of disease-associated PrPSc.
transcription profiling by array, co-expression, disease state design, in vivo
Transcriptome analysis of CNS immediately before and after the detection of PrP(Sc) in SSBP/1 sheep scrapie. Gossner AG, Hopkins J. :201-207 (2014), PMID:25183238
Transcriptome analysis of CNS immediately before and after the detection of PrPSc in sheep scrapie. Anton Gossner and John Hopkins.