E-MTAB-2068 - Transcription profiling by array of human CD8-positive T cells from patients with LGL leukemia
Released on 14 November 2013, last updated on 3 June 2014
LGL leukemia is chronic clonal lymphoproliferative disorder, characterized by expansion of cytotoxic CD8+ T-cells or NK-cells. We compared gene expression of 2 LGL leukemia patients with STAT3 mutation (Patients 11 and 12) and 2 LGL leukemia patients without STAT3/STAT5b mutation (Patients 9 and 10) with CD8 and CD4 samples from healthy controls to assess different gene expression patterns between samples.
transcription profiling by array, co-expression, disease state, in vitro
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation. Andersson EI, Rajala HL, Eldfors S, Ellonen P, Olson T, Jerez A, Clemente MJ, Kallioniemi O, Porkka K, Heckman C, Loughran TP, Maciejewski JP, Mustjoki S. :e168 (2013), PMID:24317090
Novel Somatic Mutations in Large Granular Lymphocytic Leukemia affecting the STAT-pathway and T-cell activation. Emma I Andersson, Hanna L M Rajala, Samuli Eldfors, Pekka Ellonen, Thomas Olson, Andres Jerez, Michael J. Clemente, Olli Kallioniemi, Kimmo Porkka, Caroline Heckman, Thomas P. Loughran Jr., Jaroslaw P. Maciejewski and Satu Mustjoki.