E-MTAB-2029 - Transcription profiling by array of heart tissues from rats with different duration of triiodothyronine (T3)-induced hyperthyroidism and from normal control rats
Released on 29 October 2013, last updated on 13 July 2015
Although it is well known that the thyroid hormone (T3) is an important positive regulator of cardiac function over a short-term and that it also promotes deleterious effects over a long-term, the molecular mechanisms for such effects are not well understood yet. Since most alterations in cardiac function are associated to changes on sarcomeric machinery, the present work was undertaken in order to find novel sarcomeric hot spots driven by T3 in the heart. We analysed gene expression changes in heart of rats submitted to experimental hyperthyroidism through microarray analysis. The timeline analysis included euthyroid group as control, 12, 24 hours and 7 days treatment groups.
transcription profiling by array, co-expression, in vivo, stimulus or stress
M-PROTEIN IS DOWN-REGULATED IN CARDIAC HYPERTROPHY DRIVEN BY THYROID HORMONE IN RATS. ANDREI ROZANSKI; ANA PAULA C. TAKANO; PATRICIA N. KATO; ANTONIO G. SOARES; CAMILO LELLIS-SANTOS; JULIANE CRUZ CAMPOS; JULIO CESAR BATISTA FERREIRA; MARIA LUIZA M. BARRETO-CHAVES; ANSELMO S. MORISCOT.