E-MTAB-1888 - Transcription profiling by array of rat vascular smooth muscle cells (VSMCs) grown on a micro-patterned groove substrate

Status
Released on 14 November 2013, last updated on 2 May 2014
Organism
Rattus norvegicus
Samples (6)
Array (1)
Protocols (9)
Description
Loss of contractility and acquisition of an epithelial phenotype of vascular smooth muscle cells (VSMCs) are key events in proliferative vascular pathologies such as atherosclerosis and post-angioplastic restenosis. There is no proper cell culture system allowing VSMC differentiation so that it is difficult to delineate the molecular mechanism responsible for proliferative vasculopathy. We investigated whether a micro-patterned substrate could restore the contractile phenotype of VSMCs in vitro. To induce and maintain the differentiated VSMC phenotype in vitro, we introduced a micro-patterned groove substrate to modulate the morphology and function of VSMCs.
Experiment types
transcription profiling by array, co-expression, growth condition design, in vitro
Contact
Citation
Phenotypic modulation of primary vascular smooth muscle cells by short-term culture on micropatterned substrate. Chang S, Song S, Lee J, Yoon J, Park J, Choi S, Park JK, Choi K, Choi C. PLoS One 9(2):e88089 (2014), Europe PMC 24505388
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MTAB-1888.idf.txt
Sample and data relationshipE-MTAB-1888.sdrf.txt
Raw data (2)E-MTAB-1888.raw.1.zip, E-MTAB-1888.raw.2.zip
Processed data (1)E-MTAB-1888.processed.1.zip
Array designA-AFFY-160.adf.txt
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