E-MTAB-1882 - Transcription profiling by array of well-grown compared to not-grown human uterine fibroid xenografts in immunodeficient mice to help understand huamn uterine fibroid disease
Released on 1 May 2014, last updated on 3 June 2014
Human uterine fibroids are benign tumors derived from the smooth muscle layers of the uterus. Fibroid disease impacts up to 50% of premenopausal women in their daily life, and accounts for up to 50% of hysterectomies in the United States. Despite the health burden they impose, the development of these tumors is barely understood. To improve our understanding of this disease, we developed and characterized a patient-derived xenograft models by transplanting small pieces of human uterine fibroid tissue subcutaneously into immunodeficient mice. Growth of the fibroid grafts was dependent on 17beta-estradiol and progesterone supplementation and maintained for up to 60 days. A gene expression profiling study was performed in order to determine molecular characteristis of well-grown compared to not-grown uterine fibroid xenografts.
transcription profiling by array, all pairs, co-expression, growth condition
DRAFT: DEVELOPMENT OF A PATIENT DERIVED UTERINE FIBROID XENOGRAFT MODEL IN SCID MICE PREDICTIVE FOR THE IN SITU DISEASE. Martin Fritsch, Nicole Schmidt, Jörg Müller, Ina Gröticke, Anna-Lena Frisk, Anette Sommer, Christopher Keato, Markus Koch, Ov D. Slayden.