E-MTAB-1852 - Transcription profiling by array of human glioma samples of different tumour types and grades to identify gene signatures associated with these categories
Last updated on 2 September 2013, released on 1 October 2013
Tumour expression profiling was performed on resected brain tumour tissue following its histological categorisation. Classification of tumour type was carried out according to WHO criteria by a panel of independent pathologists across the etumour consorteum. This gave a high quality diagnostic evaluation, enabling stratification of patients by tumour type and grade. Sample quality was further assessed throughout sample processing allowing the use of minimum quality standards to be applied to all samples prior to profiling. This approach yielded high quality data that combined with diagnostic stratification enabled profiling by tumour type and grade, allowing the identification and investigation of gene signatures associated with these categories.
transcription profiling by array, co-expression, disease state, in vivo
Kallmann syndrome-associated anosmin-1 contributes to brain tumor malignancy through integrin signal pathways. Catherine T. Choy, Haseong Kim, Ji-Young Lee, David M. Williams, David Palethorpe , Greg Fellows, Alan J. Wright, Ken Laing, Leslie R. Bridges, Franklyn A. Howe and Soo-Hyun Kim.