E-MTAB-1784 - Transcription profiling by array of four types of human primary decidual natural killer (NK) cells co-cultured with either 721.221-parent cells (221.PAR) or the same cells expressing the group 2 HLA-C allele Cw*0602 (C2)
Released on 4 April 2014, last updated on 3 June 2014
Receptors of the KIR family on maternal Natural Killer cells in the decidua are believed to bind to Ligands such as HLA-C on trophoblast cells invading into the decidua from the placenta during early pregnancy. The resulting responses regulate the extent of trophoblast invasion. Genetic studies have implicated two members of the KIR family in particular as playing an important role: KIR2DL1 and KIR2DS1. The aim of this experiment was to determine what responses are generated when decidual NK cells bearing either KIR2DL1 or KIR2DS1 engage their HLA-C ligand.
transcription profiling by array, co-expression, in vitro, stimulus or stress
Maternal activating receptor KIR2DS1 on uterine NK cells enhances placentation. Shiqiu Xiong, Andrew M Sharkey, Philippa R. Kennedy, Lucy Gardner, Lydia E Farrell, Olympe Chazara, Julien Bauer, Susan E Hiby, Francesco Colucci, Ashley Moffett.
Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation. Xiong S, Sharkey AM, Kennedy PR, Gardner L, Farrell LE, Chazara O, Bauer J, Hiby SE, Colucci F, Moffett A. :4264-4272 (2013), Europe PMC 24091323