E-MTAB-1765 - Transcription profiling by array of muscle and liver tissue from arthritic and non-arthritic mice treated with several doses of prednisolone
Released on 10 November 2013, last updated on 3 June 2014
Prednisolone is a potent anti-inflammatory glucocorticoid (GC) but chronic use is hampered by metabolic side effects. Although GCs are predominantly prescribed for treatment of inflammatory conditions, little is known about their long-term effects on gene-expression in-vivo during inflammation. Here, we aimed to identify genes underlying prednisolone-induced metabolic side effects in a complex in-vivo inflammatory setting after long-term treatment. We performed whole-genome expression profiling in liver and muscle from arthritic and non-arthritic mice treated with several doses of prednisolone for three weeks.
transcription profiling by array, co-expression, compound treatment design, dose response design, in vivo
Identification of gene signatures for prednisolone-induced metabolic dysfunction in collagen-induced arthritis mice. Sandrine Ellero-Simatos, Wilco W. M. Fleuren, Susanne Bauerschmidt, Wim H.A. Dokter and Erik J.M. Toonen.
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance. Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA. :None (2016), Europe PMC 27261776