E-MTAB-1688 - Transcription profiling by array of human pulmonary and circulating CD8 cells from chronic obstructive pulmonary disease (COPD) patients
Released on 1 August 2013, last updated on 13 May 2014
Background: CD8 cells seem to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, relatively little is known about their phenotype and function. Aims: To define the transcriptome of pulmonary CD8 cells in COPD and compare to paired circulating CD8 cells and smoker control pulmonary CD8 cells. COPD was defined according to the Global initiative for chronic Obstructive Lung Disease guidelines. Severity of disease was defined according to the patients lung function. In particular the forced evpiratroy volume in 1 second (FEV1).
transcription profiling by array, co-expression, disease state design, in vitro
Down Regulation of T Cell Receptor Expression in COPD Pulmonary CD8 Cells. Grundy S, Plumb J, Lea S, Kaur M, Ray D, Singh D. PLoS One 8(8):e71629 (2013), Europe PMC 23977094
Down regulation of T cell receptor expression in COPD pulmonary CD8 cells. Grundy S, Plumb J, Lea S, Kaur M, Ray D, Singh D. :e71629 (2013), Europe PMC 23977094