E-MTAB-1491 - Transcription profiling by array of human HuS-E/2 2D and 3D cultered cells to identify novel factors which support HCV proliferation
Released on 10 December 2013, last updated on 3 May 2014
HCV proliferation is closely related to three-dimentional cellular condition. In case of blood-borne (bb) HCV culture in HuS-E2 cells, bbHCV was reproduced only from 3D-cultured cells in hollow fibers. Thus, in order to identify novel factors which support HCV proliferation under three-dimentional condition, we compared gene expression profile between 2D- and 3D-cultured HuS-E/2 cells with 3D-gene Human oligo chip 25k (Toray, Tokyo, Japan).
transcription profiling by array, cell type comparison, co-expression, in vitro
Thromboxane A2 synthase inhibitors prevent production of infectious hepatitis C virus in mice with humanized livers. Abe Y, Aly HH, Hiraga N, Imamura M, Wakita T, Shimotohno K, Chayama K, Hijikata M. Gastroenterology (2013), Europe PMC 23684750