E-MTAB-1482 - ARR (Adamantyl Retinoid Related molecules)-miRNA-Cancer
Last updated on 9 June 2014, released on 30 June 2015
The adamantly-substituted retinoid related (ARR) molecules have been found to induce apoptosis in a variety of malignant cells both in vitro and in vivo. A number of mechanisms have been proposed by which apoptosis is achieved by this class of molecules. We have previously demonstrated that ARRs are potent inducers of apoptosis in leukemia and pancreatic cancer cells. We designed experiments that the exposure of leukemia and pancreatic cancer cell lines to the 3-Cl-AHPC ((E)-4-[3-(1-adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid )may result in the modulation of microRNA expression or repression and that this differential microRNA expression may contribute to ARR-mediated inhibition of cellular proliferation and cell death induction.
microRNA profiling by array, cellular modification, co-expression, in vitro
Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R. Farhana L., Dawson M.I., Murshed F., Das J.K., Rishi A.K., Fontana J.A.