E-MTAB-1422 - Transcription profiling by array of human precusor B cell subsets from children and adults
Released on 1 July 2013, last updated on 28 October 2015
Through differentiation-stage dependent analysis and pair wise comparisons between children and adults of 5 precursor B cell subsets, we identified several mechanisms that suggest tighter checkpoint control in adult precursor B cells.
transcription profiling by array, all pairs, co-expression, development or differentiation
Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output. Jensen K, Rother MB, Brusletto BS, Olstad OK, Dalsbotten Aass HC, van Zelm MC, Kierulf P, Gautvik KM. , Europe PMC 23825313
Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin. Rother MB, Jensen K, van der Burg M, van de Bovenkamp FS, Kroek R, van IJcken WF, van der Velden VH, Cupedo T, Olstad OK, van Dongen JJ, van Zelm MC. :33924 (2016), Europe PMC 27658954
Transcriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations. Jensen K, Brusletto BS, Aass HC, Olstad OK, Kierulf P, Gautvik KM. :e70721 (2013), Europe PMC 23936243