E-MTAB-1319 - Comparative genomic hybridization by array of H. sapiens endotherial progenitor cell-derived induced pluripotent stem cells to investigate genomic aberrations
Released on 4 April 2014, last updated on 3 May 2014
Human induced pluripotent stem cells (hIPSCs) represent a unique opportunity for regenerative medicine since they offer the prospect of generating unlimited quantities of cells for autologous transplantation as a novel treatment for a broad range of disorders. It is now known that primary iPS cells often carry genomic aberrations and these abnormality may compromise their possibility of clinical application. We analysed primary hIPSC lines derived from monoclonal human endothelial progenitor cell lines by array-based comparative genomic hybridisation.
comparative genomic hybridization by array, array platform comparison, comparative genome hybridization, individual genetic characteristics
Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells. Rouhani FJ, Nik-Zainal S, Wuster A, Li Y, Conte N, Koike-Yusa H, Kumasaka N, Vallier L, Yusa K, Bradley A. :e1005932 (2016), Europe PMC 27054363