E-MTAB-1297 - Transcription profiling by high throughput sequencing of mouse livers with different relative nuclear sizes before/after hepatectomy from Cdk1-null knockout and wild-type animals
Last updated on 24 February 2014, released on 6 March 2014
A partially hepatectomized mouse liver with a liver-specific conditional Cdk1 knock-out genotype grows back to the normal size in the absence of cell divisions resulting in highly enlarged nuclear and cell size. This experiment analyses gene expression in four sets of mouse livers all with different nuclear sizes: controls without hepatectomy, controls with hepatectomy, Cdk1 null without hepatectomy and Cdk1 null with hepatectomy.
RNA-seq of coding RNA, co-expression, genetic modification, in vivo
Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size. Teemu P. Miettinen, Heli K.J. Pessa, Matias J. Caldez, Tobias Fuhrer, M. Kasim Diril, Uwe Sauer, Philipp Kaldis and Mikael Björklund. Current Biology (2014)