E-MTAB-1271 - Genetic profiling of glioblastoma neural stem cells and reprogrammed derivatives
Released on 15 March 2013, last updated on 23 September 2017
Glioblastoma-derived neural stem (GNS) cells were reprogrammed to induced pluripotent stem (iPS) cells by transgenic expression of OCT4 and KLF4. Copy number status was determined for GNS and iPS cells to assess potential karyotype changes resulting from the reprogramming process.
genotyping by array, genotyping, individual genetic characteristics, reference
Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner. Stefan H. Stricker, Andrew Feber, Pär G. Engström, Helena Carén, Kathreena M. Kurian, Yasuhiro Takashima, Colin Watts, Michael Way, Peter Dirks, Paul Bertone, Austin Smith, Stephan Beck, Steven M. Pollard. Genes and Development 27(6):654-69 (2013), Europe PMC 23512659