E-MTAB-127 - Transcription profiling of the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates
Released on 2 December 2009, last updated on 3 June 2014
The aim of this experiment was to use global gene expression profiling to identify genes that are differentially expressed in the islets from Pdx1+/- mice compared to islets isolated from Pdx1 +/+ littermates. The Pdx1 null mutation consists of a nuclear targeted _-galactosidase cassette fused in-frame with the N terminus of PDX-1.
transcription profiling by array, co-expression, dye swap, genetic modification
Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress. Sachdeva MM, Claiborn KC, Khoo C, Yang J, Groff DN, Mirmira RG, Stoffers DA. Proc Natl Acad Sci U S A. 106(45):19090-5 (2009)