E-MTAB-1244 - NFATc1 cooperates with KrasG12D to promote pancreatic carcinogenesis
Last updated on 3 May 2014, released on 30 June 2014
Primary murine pancreatic cancer cells (referred to as NKC cells) derived from transgenic mice with pancreas-specific constitutive activation of NFATc1 and KrasG12D mutation in the presence or absence of NFATc1 expression were analyzed for target gene signatures.
transcription profiling by array, in vitro
NFATc1 integrates STAT3 inflammatory signals to promote KrasG12D-driven carcinogenesis in the pancreas. Sandra Baumgart, Nai-ming Chen, Jens Siveke, Jin-San Zhang, Alexander König, Shiv K. Singh, Elmar Wolf, Marek Bartkuhn, Irene Esposito, Johanna Reinecke, Caroline Klindt, Julius Nikorowitsch, Garima Singh, Kristina Reutlinger, Bettina Geisel, Heidi Griesmann, Lukas Rycak, Martin E. Fernandez-Zapico, Antonio Aliprantis, Daniel Murphy, Martin Eilers, Daniel D. Billadeau, Thomas Gress and Volker Ellenrieder.