E-MTAB-1215 - Comparative genomic hybridization by array of human glioblastoma samples to asses intra-tumoral heterogeneity in copy number abberations
Released on 15 February 2013, last updated on 9 May 2013
Glioblastoma multiforme (GBM) is a highly heterogeneous disease that shows an wide range of genetic abnormalities in comparison to other astrocytic tumors. We have extracted between 4 and 8 tumor subsamples from different areas of the malignant tissue that were at least 1cm apart. Our aim to asses the intra-tumoral heterogeneity by comparing copy number aberrations in different tumor areas to uncover important dynamics underlying GBM progression.
comparative genomic hybridization by array, disease state, ex vivo
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Andrea Sottoriva, Inmaculada Spiteri, Sara Piccirillo, Anestis Touloumis, Peter Collins, Chritsina Curtis, John Marioni, Colin Watts, Simon Tavare. Proc Natl Acad Sci USA 110(10):4009-4014 (2013), PMID:23412337
Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone. Piccirillo SG, Spiteri I, Sottoriva A, Touloumis A, Ber S, Price SJ, Heywood R, Francis NJ, Howarth KD, Collins VP, Venkitaraman AR, Curtis C, Marioni JC, Tavaré S, Watts C. :194-202 (2015), PMID:25406193
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Andrea Sottoriva; Inmaculada Spiteri; Sara G. M. Piccirillo; Anestis Touloumis; V. Peter Collins; John C. Marioni; Christina Curtis; Colin Watts; Simon Tavare. Proc Natl Acad Sci U S A 110(10):4009 (2013), PMID:23412337