E-MTAB-1168 - Transcription profiling by array of rat heart tissue treated with saline or doxorubicin to identify molecular mechanisms of doxorubicin cardiac toxicity
Released on 1 July 2012, last updated on 3 May 2014
Doxorubicin induces cardiomypathy in oncology patients. This study is aimed at identifying molecular mechanisms of doxorubicin cardiac toxicity in rats. Transcription profiling of heart tissue of rats treated with saline or doxorubicin 1, 2 or 3 mg/kg/week by iv once per week for 2, 4 or 6 weeks. Some animals were allowed to recovery from drug administration for 2 or 4 weeks. Note the recovery column refers to whether an animal was let without drug for some weeks before sacrifice.
transcription profiling by array, compound treatment, dose response, in vivo, time series
Perturbation of microRNAs in rat heart during chronic doxorubicin treatment. Caterina VACCHI-SUZZI, Yasmina BAUER, Brian R. BERRIDGE, Sandrine BONGIOVANNI, Kevin GERRISH, Hisham K. HAMADEH, Martin LETZKUS, Jonathan LYON, Jonathan MOGGS, Richard S. PAULES, François POGNAN, Frank STAEDTLER, Martin P. VIDGEON-HART, Olivier GRENET, Philippe COUTTET.