E-MTAB-1130 - Transcription profiling by high throughput sequencing of rhesus macaques vaccinated with two regimens to define correlates of protection against repeated low dose simian immunodeficiency virus challenges
Last updated on 27 September 2013, released on 28 September 2013
The study was undertaken to define correlates of protection against repeated low dose rectal SIVmac251 challenges in rhesus macaques (RMs) vaccinated with two regimens. Two groups of six RMs were immunized with either the attenuated SIVdeltanef virus, which establishes a persistent low-level infection and induces protective immunity against high dose challenges with SIVmac, or with two doses of an AdHu5 vector expressing Gag of SIVmac239 (AdHu5gag), that was given at a two-month interval.
RNA-seq of coding RNA, disease state, high throughput sequencing
Correlates of relative resistance against low-dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of vaccinated rhesus macaques. Raj Kurupati; Steve Tuyishime; Andrew V. Kossenkov; Marina Sazanovich; Larissa H. Haut; Marcio O. Lasaro; Sarah J. Ratcliffe; Steven E. Bosinger; Diane G. Carnathan; Mark Lewis; Louise C. Showe; Guido Silvestri; Hildegund C. J. Ertl. J Leukoc Biol 93(3):437 (2013), PMID:23271702
Immunological and molecular correlates of protection against low dose rectal simian immunodeficiency virus challenges in peripheral blood mononuclear cells of rhesus macaques. Kurupati, R., Tuyishime, S., Kossenkov, A.V., Sazanovich, M., Haut L.H., Lasaro M.O., Ratcliffe, S., Bosinger S., Lewis, M., Showe L.S., Silvestri G. and Ertl, H.C.J.