E-MTAB-1038 - Transcription profiling by array of human plasma cells from myeloma patients to study molecular signatures of centrosome abnormalities
Released on 21 March 2013, last updated on 3 May 2014
A large number of cancer-associated proteins involved in the cell cycle, DNA repair, chaperoning and nucleocytoplasmic transport etc. are involved in the control of centrosome number, duplication, centrosome formation and have been implicated as origin of centrosome abnormalities in cancer. In this study, we performed gene expression profiling with focusing on centrosome-related genes for determining the molecular signature characteristic for centrosome abnormalities in MM patients.
transcription profiling by array, in vitro, is expressed
Molecular Signature of Centrosome Abnormalities in Multiple Myeloma. Kryukov, Nemec, Dementyeva, Kubiczkova, Ihnatova, Budinska, Jarkovsky, Sevcikova, Kuglik, Hajek.
Centrosome associated genes pattern for risk sub-stratification in multiple myeloma. Kryukov F, Nemec P, Radova L, Kryukova E, Okubote S, Minarik J, Stefanikova Z, Pour L, Hajek R. :150 (2016), Europe PMC 27234807