E-MEXP-834 - Transcription profiling by array of liver from Ercc1 knock-out mice
Released on 21 December 2006, last updated on 19 May 2014
To investigate the cause of the premature aging features in the Ercc1-/- mouse, we compared the entire transcriptome of the Ercc1-/- mouse liver to that of wildtype littermates at the age of 15 days, when the Ercc1-/- mice reached their maximal weight and had symptoms of progeria, yet overall pathology was still limited. The liver was selected because the tissue showed several well-defined histological changes associated with aging (polyploidy and intranuclear inclusions) as well as evidence that it is responding to endogenous genotoxic stress (stabilized p53).
transcription profiling by array, disease state, genetic modification
George A Garinis <email@example.com>, Jan H Hoeijmakers, Laura J Niedernhofer
A novel progeria caused by a DNA repair defect reveals that genotoxic stress suppresses the somatotroph axis. Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, Appeldoorn E, Odijk H, Oostendorp R, Ahmad A, van Leeuwen W, Theil AF, Vermeulen W, van der Horst GT, Meinecke P, Kleijer WJ, Vijg J, Jaspers NG, Hoeijmakers JH. , Europe PMC 17183314