E-MEXP-536 - Transcription profiling of pancreatic islet implanted transgenic (expressing survivini) in mice
Submitted on 16 January 2006, released on 16 January 2006, last updated on 2 May 2014
Transgenic mice were generated that expressed the inhibitor of apoptosis and mitotic regulator survivin in pancreatic islet beta cells. Control non-transgenic or transgenic islets were then used in a model of islet transplantation in diabetic recipient mice and tested for their ability to correct hyperglycemia and allow long-term engraftment of tranplanted islets in vivo. Control or transgenic islets were analyzed by chip microarray for potential transcriptional changes associated with transgenic expression of survivin, in vivo.
transcription profiling by array, individual genetic characteristics
Dario C Altieri <email@example.com>, Charlotte Ariyan, Giacomo P Basadonna, Marco Costa, Takehiko Dohi, Whitney Salz
Inhibition of apoptosis by survivin improves transplantation of pancreatic islets for treatment of diabetes in mice. Takehiko Dohi; Whitney Salz; Marco Costa; Charlotte Ariyan; Giacomo Basadonna; Dario Altieri. EMBO Rep