E-MEXP-477 - Transcription profiling of thrombin stimulated human microvascular endothelial cell line-1 (HMEC1) over time and vs untreated cells
Released on 20 January 2006, last updated on 28 May 2012
Thrombin exerts pleiotropic effects on the endothelium. Nevertheless, little is known about its capacity to generate endothelial microparticles, a hallmark of endothelial activation. To gain insight into the mechanisms involved in microparticles release, the human microvascular endothelial cell line-1 (HMEC1) was stimulated with thrombin at 1 IU/ml for different times. The gene expression profiling in stimulated HMEC-1 was compared to that obtain with untreated cells.
cellular process, physiological process, time series, transcription profiling by array
Francine Anfosso <email@example.com>, Dignat-George Francoise, Nguyen catherine, Sampol Jose, Sapet cedric, Simoncini stéphanie