E-MEXP-463 - Transcription profiling of E. coli LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes treated with norfloxacin
Released on 5 November 2005, last updated on 3 May 2014
Effect of supercoiling level on gene expression using LZ41 and LZ54 strains containing drug-resistant alleles of different topoisomerase genes. LZ41 strain treatment with norfloxacin strongly relaxes DNA, whereas in LZ54 strain the same treatment generates high negative supercoiling (Khodursky et al., 1995, PNAS 92:11801-5; Ziechedrich et al, 1997, Genes Dev. 11:2580-92).
growth condition, strain or line, transcription profiling by array
Georgi Muskhelishvili <firstname.lastname@example.org>, Andrew Travers, Marcel Geertz, Nicolas Blot, Ramesh Mavathur