E-MEXP-3859 - Transcription profiling by array of lesional and non-lesional bulge cells from Lichen planopilaris (LPP) patients
Released on 4 July 2013, last updated on 3 May 2014
Lichen planopilaris (LPP) is a chronic inflammatory disease of unknown pathogenesis that leads to permanent hair loss. Whilst destruction of epithelial hair follicle stem cells (eHFSCs) that reside in an immunologically protected niche of the HF epithelium, the bulge, is a likely key event in LPP pathogenesis, this remains to be demonstrated. Laser capture microdissection of bulge cells from biopsies of lesional and non-lesional scalp skin from adult LPP patients were analyzed by microarray analysis.
transcription profiling by array, clinical history, co-expression, in vivo
Lichen planopilaris is characterized by immune privilege collapse of the hair follicles epithelial stem cell niche. Harries MJ, Meyer K, Chaudhry I, Kloepper J, Poblet E, Griffiths CE, Paus R. The Journal of Pathology (2013), Europe PMC 23788005