E-MEXP-3859 - Transcription profiling by array of lesional and non-lesional bulge cells from Lichen planopilaris (LPP) patients

Status
Released on 4 July 2013, last updated on 3 May 2014
Organism
Homo sapiens
Samples (16)
Array (1)
Protocols (7)
Description
Lichen planopilaris (LPP) is a chronic inflammatory disease of unknown pathogenesis that leads to permanent hair loss. Whilst destruction of epithelial hair follicle stem cells (eHFSCs) that reside in an immunologically protected niche of the HF epithelium, the bulge, is a likely key event in LPP pathogenesis, this remains to be demonstrated. Laser capture microdissection of bulge cells from biopsies of lesional and non-lesional scalp skin from adult LPP patients were analyzed by microarray analysis.
Experiment types
transcription profiling by array, clinical history, co-expression, in vivo
Contact
Citation
Lichen planopilaris is characterized by immune privilege collapse of the hair follicles epithelial stem cell niche. Harries MJ, Meyer K, Chaudhry I, Kloepper J, Poblet E, Griffiths CE, Paus R. The Journal of Pathology  (2013), Europe PMC 23788005
MIAME
PlatformsProtocolsVariablesProcessedRaw
Files
Investigation descriptionE-MEXP-3859.idf.txt
Sample and data relationshipE-MEXP-3859.sdrf.txt
Raw data (2)E-MEXP-3859.raw.1.zip, E-MEXP-3859.raw.2.zip
Processed data (1)E-MEXP-3859.processed.1.zip
Array designA-MEXP-2246.adf.txt
Links