E-MEXP-3836 - Transcription profiling by array of rat beta-cell line INS-1 to investigate the therapeutic efficacy of beta-cells with Insulin Receptor manipulation
Released on 11 June 2013, last updated on 3 May 2014
To investigate the therapeutic efficacy of beta-cells with IR manipulation, a plasmid containing human IR was stably introduced into rat beta-cell line INS-1 cells (namely, INS-IR cells). In the INS-IR cells, the role of cross-talk between insulin and Wnt signaling pathways in improving the functionality of beta-cells was investigated.
transcription profiling by array, co-expression, genetic modification design, in vitro
Insulin receptor-overexpressing β-cells ameliorate hyperglycemia in diabetic rats through Wnt signaling activation. Kim MH, Hong SH, Lee MK. :e67802 (2013), Europe PMC 23874448
Insulin Receptor-Overexpressing beta-Cells Ameliorate Hyperglycemia in Diabetic Rats through Wnt Signaling Activation.