E-MEXP-3778 - Transcription profiling by array of human fibroblast cell line WI38 expressing shCt or shUbc9 to analyse transcriptionnal changes in cells were sumoylation pathway is inactivated
Released on 25 November 2013, last updated on 19 October 2015
mRNA profiling of WI38 expressing shCt or shUbc9 4 days post-infection. The goals of this study is to analyse transcriptionnal changes in cells were sumoylation pathway is inactivated and to compare them with ChIPseq data for several histones marks and proteins of the SUMO machinery.
transcription profiling by array, cellular modification, co-expression, in vitro
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation. Neyret-Kahn H, Benhamed M, Ye T, Le Gras S, Cossec JC, Lapaquette P, Bischof O, Ouspenskaia M, Dasso M, Seeler J, Davidson I, Dejean A. Genome Res 23(10):1563 (2013), Europe PMC 23893515