E-MEXP-3670 - Transcription profiling by array of human HT29 cells infected by different wild-type rota virus strains to identify common human host genes involved in pathogenesis of different rota virus
Last updated on 29 October 2012, released on 30 June 2013
In this study, we aim to identify common human host genes involved in pathogenesis of different rota virus strains as an attempt to recognize probable antiviral targets. We have compared the host gene regulation after infection of human intestinal cell line (HT29) with three different wild type RV strains i.e. SA11 (simian, G3, P2), A5-13 (bovine, G8, P1) and Wa (human, G1, P8). HT29 cells mock infected or infected with three rota virus strains (SA11, A5-13, Wa). At 5hpi total RNA was extracted and microarray was done using Affymetrix protocol.
transcription profiling by array, co-expression, in vitro, transcript identification
Identification of common human host genes involved in pathogenesis of different rota virus strains: an attempt to recognize probable antiviral targets.