E-MEXP-3469 - Role of JunD in macrophage activation under LPS stimulation
Released on 1 April 2013, last updated on 4 May 2017
To investigate the effects of the differences seen in the JUND binding patterns between LEW, WKY and WKY.LCrgn2 bone marrow derived macrophages (BMDMs), we have 1) analysed gene expression changes over a time course (4 time points: 0,2,4 and 8 hrs) of stimulation with lipopolysaccharide (LPS) using whole transcript expression microarrays, 2) knocked down JunD in WKY BMDMs and analysed gene expression by microarrays.
transcription profiling by array, co-expression, compound treatment, genetic modification, in vitro, reference, time series
JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis. Srivastava PK, Hull RP, Behmoaras J, Petretto E, Aitman TJ.
Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1β synthesis in macrophages. Hull RP, Srivastava PK, DSouza Z, Atanur SS, Mechta-Grigoriou F, Game L, Petretto E, Cook HT, Aitman TJ, Behmoaras J. , Europe PMC 23398888