E-MEXP-3323 - Retinal vessel microarray
Released on 13 September 2013, last updated on 3 June 2014
Mus musculus, Rattus norvegicus
We sought to identify differentially expressed genes in several animal models of a retinal disease exhibiting vascular abnormalities and/or angiogenesis compared to control animals. Retinal microvessels were isolated from three models (RD1, Grhl3ct (Curlytail), VLDLR knock-out) and one rat model (RCS dystrophic rat), as well as from C57BL/J6 mice and non-dystrophic RCS rats as controls. Animals were used at ages appropriate to the age of vascular change of each model. Microvessels were isolated from the retinas and RNA was extracted and used in the microarray.
transcription profiling by array, co-expression, disease state, in vivo, species
Apelin is required for non-neovascular remodelling in the retina.