E-MEXP-270 - Transcription profiling of chicken Pax5 deficient DT40 B cell line
Released on 17 April 2005, last updated on 2 May 2014
PAx5 is indispensible for the committment if early lymphoid progenitors to the B cell lineage as well as for the development and maintenance of B cells. To better understand the functional importance of Pax5 in the later stages of B cell development and investigate the targets of Pax5 regulation, we established a novel Pax5 deficient DT40 B cell line.
transcription profiling by array, genetic modification
Loss of Pax5 promotes plasma cell differentiation. Nera, K. -P., Kohonen, P., Narvi, E., Peippo, A., Mustonen, L., Terho, P. Buerstedde, J. -M. & Lassila, O.