E-MEXP-228 - Transcription profiling of human regulatory T cells to identify genes under Foxp3 control
Released on 24 January 2005, last updated on 2 May 2014
Foxp3, a transcription factor of the forkhead/winged helix family, plays a unique role in the transcriptional control of regulatory CD4+CD25+ T (Treg) cells. The identification of potential target genes associated with the regulatory phenotype and the characterization of combinatorial interactions of transcription factors (TF) in promoter regions in genes regulated by Foxp3 has become important to understand the transcriptional control of Treg cells.
transcription profiling by array, development or differentiation, genetic modification
Robert Geffers <firstname.lastname@example.org>, Alexander Kel, Frank Ocklenburg, Henk Garritsen, Jan Buer, Jürgen Klempnauer, Kurt E Dittmer, Lars Macke, Lothar Gröbe, Michael Probst-Kepper, Olga Kel-Margoulis, Viktoria Janke, Wiebke Hansen
Foxp3-dependent transcriptional control of human regulatory T cells. Robert Geffers; Frank Ocklenburg; Viktoria Janke; Wiebke Hansen; Henk Garritsen; Lars Macke; Kurt Dittmer; Lothar Gröbe; Jürgen Klempnauer; Olga Kel-Margoulis; Alexander Kel; Jan Buer; Michael Probst-Kepper.