E-MEXP-2153 - Transcription profiling of mouse naive T cells differentiated under TH1 and TH2 conditions
Released on 6 June 2009, last updated on 2 May 2014
Naive CD4+ CD62L+ CD25- T cells were differentiated under TH1 and TH2 conditions for 7 days, restimulated with anti-CD3 and anti-CD28 for 24h and sorted for IFN-gamma (TH1) and IL-4 (TH2) production using cytokine secretion assays.
transcription profiling by array, co-expression, in vitro, transcript identification
The AP-1 transcription factor Batf controls T(H)17 differentiation. Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM. Nature 460(7253):405-9 (2009), PMID:19578362