E-MEXP-209 - Transcription profiling of wounds from ovariectomized MIF null mice and controls to investigate the role of MIF during wound healing using BALB/C MIF null mice
Released on 5 November 2005, last updated on 2 May 2014
The aim of this experiment was to investigate the role of MIF during wound healing using BALB/C MIF null mice and in the context of reduced estrogen-associated impaired healing using ovariectomized mice (a mouse model of age-associated delayed healing). Ageing is associated with delayed cutaneous wound healing resulting from reduced estrogen levels. Macrophage migration inhibitory factor (MIF - NCBI RefSeq: NM_010798) is thought to mediate the effects of estrogen on wound healing. Gene expression was compared between wounds from ovariectomized MIF null mice and controls.
transcription profiling by array, genetic modification, injury
Macrophage Migration Inhibitory Factor: A Central Regulator of Wound Healing. Hardman, Matthew J.; Waite, Alexander; Zeef, Leo; Burow, Matthew; Nakayama, Toshinori; Ashcroft, Gillian S.