E-MEXP-1397 - Transcription profiling of wild type, p53 Ser389 phosphorylation site point mutant and p53 knock-out mouse embryonic fibroblasts after exposure to UV radiation for different lengths of time
Released on 1 June 2008, last updated on 2 May 2014
Comparison of responses of mouse wild-type, p53 Ser389 phosphorylation site point mutant and full knock-out mutant MEF cells to UV-C-radiation in time
transcription profiling by array, co-expression, injury, reference, time series
Absence of Ser389 phosphorylation in p53 affects the basal gene-expression level of many p53-dependent genes and alters the biphasic response to UV exposure in MEFs. Wendy Bruins, Oskar Bruning, Martijs J. Jonker, Edwin Zwart, Tessa V. van der Hoeven, Jeroen L.A. Pennings, Han Rauwerda, Annemieke de Vries, and Timo M. Breit.